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Manganese-enhanced MR imaging of brain activation evoked by noxious peripheral electrical stimulation

Authors
 Myeounghoon Cha ; Kyuhong Lee ; Chulhyun Lee ; Jee-Hyun Cho ; Chaejoon Cheong ; Jin-Hun Sohn ; Bae Hwan Lee 
Citation
 Neuroscience Letters, Vol.613 : 13~18, 2016 
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Issue Date
2016
Abstract
As imaging technology develops, magnetic resonance imaging (MRI) has furthered our understanding of brain function by clarifying the anatomical structure and generating functional imaging data related to information processing in pain conditions. Recent studies have reported that manganese (Mn(2+))-enhanced MRI (MEMRI) provides valuable information about the functions of the central nervous system. The aim of this study was to identify specific brain regions activated during noxious electric stimulation using high-resolution MEMRI. Male Sprague Dawley rats were divided into three groups: naïve, sham electrical stimulation, and noxious electric stimulation. Under urethane with α-chloralose mixture anesthesia, a catheter was placed in the external carotid artery to administrate 20% mannitol and manganese chloride (25mM MnCl2). Noxious electric stimulation (2Hz, 10V) was applied to the hind paw with a needle electrode. Stimulation-induced neuronal activation was detected using 4.7-T MRI. In response to noxious electrical stimulation, remarkable Mn(2+)-enhanced signals were observed in the agranular insular cortex, auditory cortex, primary somatosensory cortex of the hind limb, and granular and dysgranular insular cortex, which correspond to sensory tactile electric stimulus to the hindpaws. These results indicate that the combination of MEMRI with activity-induced Mn(2+)-dependent contrast can delineate functional areas in the rat brain.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/146457
DOI
10.1016/j.neulet.2015.11.027
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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