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A Comparison of the Effects of Sevoflurane and Desflurane on Corrected QT Interval Prolongation in Patients Undergoing Living Donor Liver Transplantation: A Prospective Observational Study

Authors
 J.J. Min : J. Lee ; H.-C. Lee ; H.-G. Ryu ; M. Shin ; H.J. Kim 
Citation
 Transplantation Proceedings, Vol.48(1) : 96~101, 2016 
Journal Title
 Transplantation Proceedings 
ISSN
 0041-1345 
Issue Date
2016
Abstract
BACKGROUND: QT interval prolongation has frequently been observed in patients with advanced liver disease. We investigated the influence of inhalation anesthetics on the corrected QT (QTc) interval prolongation during surgery in patients undergoing living-donor liver transplantation. METHODS: Our study included 43 patients who were assigned to 2 groups: sevoflurane (n = 22) or desflurane anesthesia (n = 21). QTc intervals were measured at perioperative determined time points and calculated using Fridericia's formula. RESULTS: Intraoperative QTc intervals increased during the peri-intubation period versus baseline (P = .003) and were prolonged during the peri-reperfusion period (P < .001). However, there was no significant difference in intraoperative QTc interval changes between patients given sevoflurane or desflurane (P = .59). CONCLUSIONS: In this prospective observational study, there was no significant difference in QTc intervals between sevoflurane and desflurane. QTc intervals increased during intubation and reperfusion relative to preoperative values in patients given either sevoflurane or desflurane.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/146458
DOI
10.1016/j.transproceed.2015.12.034
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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