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Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women

Other Titles
 Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women 
Authors
 Hyeon Chang Kim ; Sung Hee Choi ; Hae Won Shin ; Jae Youn Cheong ; Kwan Woo Lee ; Hyun Chul Lee ; Kap Bum Huh ; Dae Jung Kim 
Citation
 World Journal of Gastroenterology, Vol.11.0(34) : 5314~5321, 2005 
Journal Title
 World Journal of Gastroenterology 
ISSN
 1007-9327 
Issue Date
2005
Abstract
AIM: To evaluate the association between the severity of liver steatosis and metabolic syndrome in apparently healthy Korean adults. METHODS: We examined 1 022 men and women, aged 30-79 years, who participated in a health screening test. A standard interview, anthropometrics, biochemical studies, and abdominal ultrasonography were conducted for each participant. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III, with a modification for the waist circumference cut-off level. The severity of liver steatosis was evaluated using liver ultrasonography, and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (gamma-GT) levels were determined. RESULTS: Ultrasonographic liver steatosis was strongly associated with metabolic syndrome and common metabolic abnormalities. Compared with people without steatosis, people with mild, moderate, and severe steatosis had adjusted odds ratios for metabolic syndrome of 1.72 (95%CI, 1.01-2.94), 2.89 (1.75-4.76) and 3.53 (1.25-9.98) in men, and 2.86 (1.64-5.01), 3.19 (1.80-5.65) and 3.70 (0.82-16.73) in women, respectively. The serum AST level was not associated with metabolic syndrome. The serum ALT and gamma-GT levels were significantly associated with metabolic syndrome in men but not in women. CONCLUSION: The occurrence of metabolic syndrome shows a stronger association with the severity of ultrasonographic steatosis than with the serum liver enzyme levels. The degree of fatty infiltration detected on ultrasonography can be used as an indicator of liver dysfunction attributable to metabolic abnormalities.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/147590
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Preventive Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
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